One Gene Links Two Different Diseases
Published:12 Jan.2018    Source:Nature
A gene associated with Parkinson’s disease might also have a role in a debilitating intestinal disorder. It was found that a link between Crohn’s disease and a particular DNA sequence in a gene called LRRK2. The variant DNA causes the LRRK2 protein to become more active than the typical protein — as does a Parkinson’s disease-associated variant in the same part of the protein. The researchers say that the findings could help to explain the mechanism underlying the two seemingly unrelated diseases.
 
Crohn’s disease is an inflammatory bowel condition that is particularly common in Ashkenazi Jewish populations. Inga Peter of the Icahn School of Medicine at Mount Sinai in New York City and her colleagues analysed gene sequences in more than 2,000 people with Crohn’s disease and 3,600 individuals without the condition, all of whom were of Ashkenazi Jewish descent.