Bioengineers program cells as digital signal processors
Published:04 Jun.2019    Source:Nanowerk

Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells. The research, described in the journal Science, dramatically expands the chemical, physical and environmental cues engineers can use to prompt programmed response from engineered organisms.


Using a biochemical process called cooperative assembly, Caleb Bashor of Rice University, Ahmad “Mo” Khalil of Boston University (BU) and colleagues from MIT, Harvard, the Broad Institute and Brandeis University engineered genetic circuits that were able to both decode frequency-dependent signals and conduct dynamic signal filtering.