A potential drug found in a sea creature can now be made efficiently in the lab
Published:20 Oct.2017    Source:ScienceNews

A seaweed-like marine invertebrate contains a molecule that has piqued interest as a drug but is in short supply: Collecting 14 tons of the critters, a type of bryozoan, yields just 18 grams of the potential medicine. Now, an efficient lab recipe might make bryostatin 1 easier to get.

 

Making more of the molecule could help scientists figure out whether the drug — which has shown mixed results in limited clinical trials for cancer, HIV and Alzheimer’s disease — will pan out or bomb.

 

Bryostatin 1, found naturally in a sea creature called Bugula neritina, has been studied as a potential drug for several decades. It interacts with an enzyme in the human body that helps regulate cell growth and control immune response. But finding a way to re-create the molecule in the lab, which would ensure a steady supply for research, has been a challenge.