How Antibodies Attack the Brain and Muddle Memory
Published:30 Aug.2018    Source:ScienceNews

 Antibodies in the brain can scramble nerve cells’ connections, leading to memory problems in mice.


In the past decade, brain-attacking antibodies have been identified as culprits in certain neurological diseases. The details of how antibodies pull off this neuronal hit job, described online August 23 in Neuron, may ultimately lead to better ways to stop the ensuing brain damage.


Research on antibodies that target the brain is a “biomedical frontier” that may have implications for a wide range of disorders, says Betty Diamond, an immunologist and rheumatologist at Northwell Health's Feinstein Institute for Medical Research in Manhasset, N.Y. “It’s beyond the idea stage,” she says. “It’s into the ‘It happens. Let’s figure out the why and the when.’ ”